Importance Imaging biomarkers in Parkinson disease (PD) are increasingly important for
monitoring progression in clinical trials and also have the potential to improve clinical care …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

The differential diagnosis of parkinsonian syndromes is considered one of the most
challenging in neurology and error rates in the clinical diagnosis can be high even at …

There is no well-established in vivo marker of nigral degeneration in Parkinson's disease
(PD). An ideal imaging marker would directly mirror the loss of substantia nigra …

Parkinson's disease (PD) is a common, progressive, and currently incurable
neurodegenerative movement disorder. The diagnosis of PD is challenging, especially in …

Background Neuroimaging studies help us better understand the pathophysiology and
symptoms of Parkinson's disease (PD). In several of these studies, diffusion tensor imaging …

Progression markers of Parkinson's disease are crucial for successful therapeutic
development. Recently, a diffusion magnetic resonance imaging analysis technique using a …

Parkinson's disease (PD) is one of the common progressive neurodegenerative disorders
with several motor and non-motor symptoms. Most of the motor symptoms may appear at a …

There is a clear need to develop non-invasive markers of substantia nigra progression in
Parkinson's disease. We previously found elevated free-water levels in the substantia nigra …

Conventional single tensor diffusion analysis models have provided mixed findings in the
substantia nigra of Parkinson's disease, but recent work using a bi-tensor analysis model …