[HTML][HTML] HRP2: transforming malaria diagnosis, but with caveats

KE Poti, DJ Sullivan, AM Dondorp, CJ Woodrow - Trends in parasitology, 2020 - cell.com
The major growth in point-of-care malaria diagnosis over the past decade has been based
on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect …

New insights into malaria pathogenesis

CA Moxon, MP Gibbins, D McGuinness… - Annual Review of …, 2020 - annualreviews.org
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …

Pathogenesis of cerebral malaria—inflammation and cytoadherence

J Storm, AG Craig - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Despite decades of research on cerebral malaria (CM) there is still a paucity of knowledge
about what actual causes CM and why certain people develop it. Although sequestration of …

Performance of C-reactive protein and procalcitonin to distinguish viral from bacterial and malarial causes of fever in Southeast Asia

Y Lubell, SD Blacksell, S Dunachie… - BMC infectious …, 2015 - Springer
Background Poor targeting of antimicrobial drugs contributes to the millions of deaths each
year from malaria, pneumonia, and other tropical infectious diseases. While malaria rapid …

Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches

PK Sahu, S Satpathi, PK Behera, SK Mishra… - Frontiers in cellular …, 2015 - frontiersin.org
Cerebral malaria is a severe neuropathological complication of Plasmodium falciparum
infection. It results in high mortality and post-recovery neuro-cognitive disorders in children …

Plasmodium falciparum histidine-rich protein II compromises brain endothelial barriers and may promote cerebral malaria pathogenesis

P Pal, BP Daniels, A Oskman, MS Diamond, RS Klein… - MBio, 2016 - Am Soc Microbiol
Cerebral malaria (CM) is a disease of the vascular endothelium caused by Plasmodium
falciparum. It is characterized by parasite sequestration, inflammatory cytokine production …

The mRNA content of plasma extracellular vesicles provides a window into molecular processes in the brain during cerebral malaria

M Kioko, S Mwangi, A Pance, LI Ochola-Oyier… - Science …, 2024 - science.org
The impact of cerebral malaria on the transcriptional profiles of cerebral tissues is difficult to
study using noninvasive approaches. We isolated plasma extracellular vesicles (EVs) from …

Laboratory detection of malaria antigens: a strong tool for malaria research, diagnosis, and epidemiology

M Plucinski, M Aidoo, E Rogier - Clinical Microbiology Reviews, 2021 - Am Soc Microbiol
The identification and characterization of proteins produced during human infection with
Plasmodium spp. have guided the malaria community in research, diagnosis, epidemiology …

Fungal and parasitic CNS infections

P Singhi, AG Saini - The Indian Journal of Pediatrics, 2019 - Springer
Central nervous system fungal infections can be broadly divided into those that infect a
healthy host such as Cryptococcus, Coccidioides, Histoplasma, Blastomyces, Sporothrix …

The mRNA content of plasma extracellular vesicles provides a window into the brain during cerebral malaria disease progression

A Abdi, K Mwikali, S Mwangi, A Pance… - Science …, 2023 - researchprofiles.herts.ac.uk
The impact of cerebral malaria on the transcriptional profiles of cerebral tissue is difficult to
study using non-invasive approaches. We isolated plasma extracellular vesicles (EVs) from …