Highlights•A diverse spectrum of viruses can enter the CNS, causing acute and chronic
neurological disorders.•Virus-induced CNS diseases are influenced by routes of viral entry …

HIV-associated central nervous system (CNS) injury continues to be clinically significant in
the modern era of HIV infection and therapy. A substantial proportion of patients with …

Transmission of HIV-1 results in the establishment of a new infection, typically starting from a
single virus particle. That virion replicates to generate viremia and persistent infection in all …

Recombination in HIV-1 is well documented, but its importance in the low-diversity setting of
within-host diversification is less understood. Here we develop a novel computational tool …

HIV-1 is completely dependent upon the Env protein to enter cells. The virus typically
replicates in activated CD4+ T cells due to viral entry requirements for the CCR5 coreceptor …

Highlights•RNA virus replication gives rise to a cloud of variants containing mutations,
insertions and deletions, some of which contribute to evolution.•Virus population diversity …

Arenavirus particles are enveloped and contain two single-strand RNA genomic segments
with ambisense coding. Genetic plasticity of the arenaviruses comes from transcription …

Although semen is the principal vector of human immunodeficiency virus (HIV)
dissemination worldwide, the origin of the infected leukocytes and free viral particles in this …

HIV-1 subtype B replication in the CNS can occur in CD4+ T cells or macrophages/microglia
in adults. However, little is known about CNS infection in children or the ability of subtype C …

Macrophages are important target cells for HIV-1 infection that play significant roles in the
maintenance of viral reservoirs and other aspects of pathogenesis. Understanding the …