A holy grail of regenerative medicine is to replenish the cells that are lost due to disease.
The adult mammalian central nervous system (CNS) has, however, largely lost such a …

Cell replacement therapy represents a promising approach for treating neurodegenerative
diseases. Contrary to the common addition strategy to generate new neurons from glia by …

Lineage reprogramming of resident glial cells to dopaminergic neurons (DAns) is an
attractive prospect of the cell-replacement therapy for Parkinson's disease (PD). However, it …

Generation of neurons through direct reprogramming has emerged as a promising
therapeutic approach for treating neurodegenerative diseases. In this study, we present an …

Background Reprogramming resident glial cells to convert them into neurons in vivo
represents a potential therapeutic strategy that could replenish lost neurons, repair …

Parkinson's disease (PD) is currently the fastest growing disabling neurological disorder
worldwide, with motor and non-motor symptoms being its main clinical manifestations. The …

Neuron loss and disruption of neural circuits are associated with many neurological
conditions. A key question is how to rebuild neural circuits for functional improvements. In …

Spinal cord injury (SCI) can lead to the loss of motor, sensory, or autonomic function due to
neuronal death. Unfortunately, the adult mammalian spinal cord has limited intrinsic …

Background Subarachnoid hemorrhage (SAH) causes significant long-term neurocognitive
dysfunction, which is associated with hippocampal neuroinflammation. Growing evidences …

In the mammalian brain, astrocytes form a heterogeneous population at the morphological,
molecular, functional, intra-, and inter-region levels. In the past, a few types of astrocytes …