Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the
brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM) …

Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Background Tuberculosis is the world's leading infectious disease killer. We aimed to
identify shorter, safer drug regimens for the treatment of tuberculosis. Methods We did a …

Background. Based on a hollow-fiber system model of tuberculosis, we hypothesize that
microbiologic failure and acquired drug resistance are primarily driven by low drug …

The history of the development of modern chemotherapy for tuberculosis (TB), largely due to
the British Medical Research Council, is first described. There is a current need to shorten …

Background. Using hollow-fiber tuberculosis studies, we recently demonstrated that
nonadherence is not a significant factor for ADR and that therapy failure only occurs after a …

Tuberculosis is an ancient human disease, estimated to have originated and evolved over
thousands of years alongside modern human populations. Despite considerable advances …

Rationale: We examined whether increased rifampin doses could shorten standard therapy
for tuberculosis without increased toxicity. Objectives: To assess the differences across three …

The introduction of rifampicin (rifampin) into tuberculosis (TB) treatment five decades ago
was critical for shortening the treatment duration for patients with pulmonary TB to 6 months …

The most accessible points of call for most African populations with respect to primary health
care are traditional health systems that include spiritual, religious, and herbal medicine. This …