Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular
glucose usage. The upregulation of GLUT s has been reported in numerous cancer types as …

Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant
subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological …

The glucose transporter family (GLUT) consists of fourteen members. It is responsible for
glucose homeostasis and glucose transport from the extracellular space to the cell …

The recent progresses in understanding of cancer glycolytic phenotype have offered new
strategies to manage ovarian cancer and other malignancies. However, therapeutic …

Glucose addiction is observed in cancer and other diseases that are associated with
hyperproliferation. The development of compounds that restrict glucose supply and …

CD4+ T cells have numerous features of over-activated cellular metabolism in lupus patients
and mouse models of the disease. This includes a higher glycolysis than in healthy controls …

Cellular metabolism plays a central role in the regulation of both innate and adaptive
immunity. Immune cells utilize metabolic pathways to modulate the cellular differentiation or …

Endothelial metabolism is a promising target for vascular functional regulation and disease
therapy. Glucose is the primary fuel for endothelial metabolism, supporting ATP generation …

In the 1920s, Otto Warburg observed the phenomenon of altered glucose metabolism in
cancer cells. Although the initial hypothesis suggested that the alteration resulted from …