MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …

Small RNAs directly or indirectly impact nearly every biological process in eukaryotic cells.
To perform their myriad roles, not only must precise small RNA species be generated, but …

Stem cells reside in specialized niches that regulate their self-renewal and differentiation.
The vasculature is emerging as an important component of stem cell niches. Here, we show …

The hallmark of a stem cell is its ability to self-renew and to produce numerous differentiated
cells. This unique property is controlled by dynamic interplays between extrinsic signalling …

Abstract MicroRNAs (miRNAs) are~ 22 nt RNAs that coordinate vast regulatory networks in
animals and thereby influence myriad processes. This Review examines evidence that …

Non-protein-coding sequences increasingly dominate the genomes of multicellular
organisms as their complexity increases, in contrast to protein-coding genes, which remain …

MicroRNAs (miRNAs) govern an expanding number of biological and disease processes.
Understanding the mechanisms by which the miRNA pathway is regulated, therefore …

Sperm and egg production requires a robust stem cell system that balances self-renewal
with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis …

In the mouse neocortex, neural progenitor cells generate both differentiating neurons and
daughter cells that maintain progenitor fate. Here, we show that the TRIM-NHL protein …

MicroRNAs (miRNAs) are small non-coding RNAs that are generated in all eukaryotes and
viruses. Their role as master regulators of gene expression in various biological processes …