Ischemic stroke (IS) is characterized by high recurrence and disability; however, its therapies
are very limited. As one of the effective methods of treating acute attacks of IS, intravenous …

Although traditionally considered a glucose metabolism-associated modification, the O-
linked β-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids …

Microglia-mediated inflammation plays an important role in the pathogenesis of several
neurodegenerative diseases including Parkinson's disease (PD). Recently, autophagy has …

Cerebral ischemia-reperfusion injury (CI/RI) is the main cause of disability and death in
stroke without satisfactory therapeutic effect. Inflammation mediated by activation of …

Although microglial activation is widely found in amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD), the underlying mechanism (s) are poorly understood. Here …

Orexin A (OXA) is a neuroprotective peptide that exerts protective effects on multiple
physiological and pathological processes. Activation of autophagy is linked to the …

NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome inhibition and
autophagy induction attenuate inflammation and improve outcome in rodent models of …

Salvinorin A (SA) is a highly selective kappa opioid receptor (KOR) agonist that has
significant protective effects on cerebrovascular function after ischemic stroke, but its …

Background Orexin-A (OXA) is a polypeptide produced in the hypothalamus, which binds to
specific receptors and exerts multiple physiological effects. Autophagy plays a vital role in …

As a membrane-permeable derivative of itaconate, dimethyl itaconate (DMI) was recently
showed to limit inflammatory response of activated macrophages, and to decrease the …