De novo discovery of thiopeptide pseudo-natural products acting as potent and selective TNIK kinase inhibitors
AA Vinogradov, Y Zhang, K Hamada… - Journal of the …, 2022 - ACS Publications
Bioengineering of ribosomally synthesized and post-translationally modified peptides
(RiPPs) is an emerging approach to explore the diversity of pseudo-natural product …
(RiPPs) is an emerging approach to explore the diversity of pseudo-natural product …
Deep Learning-Driven Library Design for the De Novo Discovery of Bioactive Thiopeptides
Broad substrate tolerance of ribosomally synthesized and post-translationally modified
peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP …
peptide (RiPP) biosynthetic enzymes has allowed numerous strategies for RiPP …
Late-Stage Minimal Labeling of Peptides and Proteins for Real-Time Imaging of Cellular Trafficking
F Nadal-Bufi, RV Nithun, F De Moliner, X Lin… - ACS Central …, 2024 - ACS Publications
The cellular uptake routes of peptides and proteins are complex and diverse, often
handicapping therapeutic success. Understanding their mechanisms of internalization …
handicapping therapeutic success. Understanding their mechanisms of internalization …
A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides
AA Vinogradov, Y Zhang, K Hamada… - Journal of the …, 2024 - ACS Publications
Thiopeptides make up a group of structurally complex peptidic natural products holding
promise in bioengineering applications. The previously established thiopeptide/mRNA …
promise in bioengineering applications. The previously established thiopeptide/mRNA …
Enantioselective total syntheses of six natural and two proposed meroterpenoids from Psoralea corylifolia
XW Chen, ZC Hou, C Chen, LH Zhang, ME Chen… - Chemical …, 2023 - pubs.rsc.org
The first enantioselective total syntheses of six natural and two proposed meroterpenoids
isolated from Psoralea corylifolia have been achieved in 7–9 steps from 2 …
isolated from Psoralea corylifolia have been achieved in 7–9 steps from 2 …
Catalytic Amide Activation with Thermally Stable Molybdenum (VI) Dioxide Complexes
GE Evenson, WC Powell, AB Hinds… - The Journal of organic …, 2023 - ACS Publications
Oxazolines and thiazolines are important constituents of bioactive natural products and
pharmaceuticals. Here, we report the development of an effective and practical method of …
pharmaceuticals. Here, we report the development of an effective and practical method of …
[PDF][PDF] 疏水载体辅助液相法与固相法合成芋螺毒素的工艺对比
张文杰， 张发进， 赵仕法， 董玉香， 郭凯… - 滨州医学院 …, 2024 - manu58.magtech.com.cn
目的对芋螺毒素μ CnIIIC 的三种二硫键异构体进行合成工艺研究及表征鉴定.
方法通过可溶性疏水载体辅助液相合成法(LPPS) 和固相多肽合成法(SPPS) 人工合成μ CnIIIC …
方法通过可溶性疏水载体辅助液相合成法(LPPS) 和固相多肽合成法(SPPS) 人工合成μ CnIIIC …