Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Eicosanoids have been implicated in a vast number of devastating inflammatory conditions,
including arthritis, atherosclerosis, pain, and cancer. Currently, over a hundred different …

Two concepts for the long-term regulation of arterial pressure were considered in this
review, the neural control hypothesis and the volume regulation hypothesis. The role of the …

There has been an explosive growth of interest in the multiple interacting paracrine systems
that influence renal microvascular function. This review first discusses the membrane …

Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …

Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

Hyperglycemia is the major causal factor in the development of diabetic vascular
complications and can mediate their adverse effects through multiple pathways. One of …

1. The CYP4 family consists of 11 subfamilies (CYP4A-CYP4M), which encode constitutive
and inducible isozymes expressed in both mammals and insects. 2. 2. The CYP4A subfamily …

Cytochrome P-450-dependent metabolites of arachidonic acid (AA) increased in the kidneys
of young, spontaneously hypertensive rats (SHRs) during the period of rapid elevation of …