Gut microbiota, the largest symbiont community hosted in human organism, is emerging as a
pivotal player in the relationship between dietary habits and health. Oral and, especially …

Background Globoid cell leukodystrophy or Krabbe disease, is a rapidly progressive
childhood lysosomal storage disorder caused by a deficiency in galactocerebrosidase …

Neurodegenerative lysosomal storage disorders (LSDs) are severe and untreatable, and
mechanisms underlying cellular dysfunction are poorly understood. We found that toxic …

In Krabbe's disease (KD), a leukodystrophy caused by β-galactosylceramidase deficiency,
demyelination and a myelin-independent axonopathy contributes to the severe …

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3, the most common
dominant spinocerebellar ataxia (SCA) worldwide, is caused by over-repetition of a CAG …

Neurological diseases with genetic etiologies result in the loss or dysfunction of neural cells
throughout the CNS. At present, few treatment options exist for the majority of neurogenetic …

Background Mesenchymal stem cells'(MSC) therapeutic potential has been investigated for
the treatment of several neurodegenerative diseases. The fact these cells can mediate a …

Transplantation of bone marrow mesenchymal stem cells (BMDCs) into a denervated side of
the spinal cord was reported to be a useful option for axonal regeneration. The innervation …

目的探讨神经生长因子(NGF) 转染的人脐带间充质干细胞(hUC-MSCs) 减轻中枢神经系统功能
损伤和促进中枢神经系统功能恢复的可行性. 方法构建缺血, 缺氧脑损伤的Wistar 大鼠模型 …

Tooth engineering may refer to either dental tissue regeneration or to the reformation of a
complete organ attached to surrounding bone [1–4]. In case of whole tooth organ …