Advances in small-molecule fluorescent probes for the study of apoptosis

YX Ye, JC Pan, HC Wang, XT Zhang, HL Zhu… - Chemical Society …, 2024 - pubs.rsc.org
Apoptosis, as type I cell death, is an active death process strictly controlled by multiple
genes, and plays a significant role in regulating various activities. Mounting research …

The multiple biological roles of the cholinesterases

I Silman - Progress in biophysics and molecular biology, 2021 - Elsevier
It is tacitly assumed that the biological role of acetylcholinesterase is termination of synaptic
transmission at cholinergic synapses. However, together with its structural homolog …

Stress responses of bivalve mollusc Unio tumidus from two areas to ibuprofen, microplastic and their mixture

V Martyniuk, B Gylytė, T Matskiv, V Khoma, H Tulaidan… - Ecotoxicology, 2022 - Springer
Even though bivalve molluscs are recognized as bioindicators of freshwater quality, their
responses to multiple stressors are unpredictable. This study aims to elucidate the inter …

The human acetylcholinesterase C-terminal T30 peptide activates neuronal growth through alpha 7 nicotinic acetylcholine receptors and the mTOR pathway

A Graur, P Sinclair, AK Schneeweis, DT Pak… - Scientific Reports, 2023 - nature.com
Acetylcholinesterase (AChE) is a highly conserved enzyme responsible for the regulation of
acetylcholine signaling within the brain and periphery. AChE has also been shown to …

A highly specific two-photon fluorescent probe for real-time monitoring of acetylcholinesterase in neurogenic disorders in vivo

W An, Z Huang, W Jiang, F Du, C Xu, Q Shen… - Analytica Chimica …, 2024 - Elsevier
Acetylcholinesterase (AChE) hydrolyses choline into thiocholine, which is essential for
cholinergic neurons to revert to their resting state following activation. Abnormal changes in …

Environmental concentrations of Roundup in combination with chlorpromazine or heating causes biochemical disturbances in the bivalve mollusc Unio tumidus

V Khoma, V Martinyuk, T Matskiv, L Gnatyshyna… - … Science and Pollution …, 2022 - Springer
Bivalve molluscs represent the most recognized bioindicators of freshwater pollution.
However, their ability to indicate specific xenobiotics in complex exposures is unclear. In this …

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis

S Wischnewski, T Thäwel, C Ikenaga, A Kocharyan… - Nature Aging, 2024 - nature.com
Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older
adults with no effective therapy available. In contrast to other inflammatory myopathies such …

Biochemical basis of resistance to multiple contaminations in the native and invasive populations of Dreissena polymorpha

T Matskiv, V Martyniuk, V Khoma, K Yunko… - … and Physiology Part C …, 2024 - Elsevier
The zebra mussel Dreissena polymorpha (Pallas, 1771) is an invasive species and a
valuable bioindicator in the inland waters. Nevertheless, the biochemical reasons for the …

Multifaceted promotion of apoptosis by acetylcholinesterase

DY Knorr, D Demirbas, R Heinrich - Frontiers in Cell Death, 2023 - frontiersin.org
Elevated expression of acetylcholinesterase (AChE) is a common characteristic of apoptotic
cells in both invertebrate and vertebrate species. While increased levels of …

Reductive stress and cytotoxicity in the swollen river mussel (Unio tumidus) exposed to microplastics and salinomycin

V Martyniuk, T Matskiv, K Yunko, V Khoma… - Environmental …, 2024 - Elsevier
Multistress effects lead to unpredicted consequences in aquatic ecotoxicology and are
extremely concerning. The goal of this study was to trace how specific effects of the antibiotic …