Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Modulating epigenetic modification has been recognized for over a decade as an effective
therapeutic approach to cancer and many studies of histone deacetylase (HDAC), one of the …

Natural killer/T cell lymphoma (NKTCL) is an aggressive and heterogeneous entity of non-
Hodgkin lymphoma, strongly associated with Epstein-Barr virus (EBV) infection. To identify …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

Immunotherapy has been applied successfully to treat B-cell lymphomas in preclinical
models or clinical settings. However, immunotherapy resistance is a major challenge for B …

Cancer cells must adapt to the hostile conditions of the microenvironment in terms of
nutrition, space, and immune system attack. Mutations of DNA are the drivers of the …

Controlling access to genomic information and maintaining its stability are key aspects of
cell life. Histone acetylation is a reversible epigenetic modification that allows access to DNA …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Epigenetic control plays an important role in gene regulation through chemical modifications
of DNA and post-translational modifications of histones. An essential post-translational …

Transcriptional networks supervising class IIa HDAC expression are poorly defined. Here
we demonstrate that MEF2D is the key factor controlling HDAC9 transcription. This control …