Combination therapy has shown an obvious efficacy on complex diseases and can greatly
reduce the development of drug resistance. However, even with high-throughput screens …

Aging is one of the world's greatest concerns, requiring urgent, effective, large-scale
interventions to decrease the number of late-life chronic diseases and improve human …

This brief perspective article focuses on the most common errors and pitfalls, as well as the
do's and don'ts in drug combination studies, in terms of experimental design, data …

Monoclonal antibodies are standard therapeutics for several cancers including the anti-
CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other …

Mimicking nature's ability to orchestrate molecular self-assembly in living cells is important
yet challenging. Molecular self-assembly has found wide applications in cellular activity …

Resveratrol (RES) is the most effective natural products used for the treatment of a variety of
cancers. In this study, we tested the effect of RES in enhancing the efficacy of docetaxel …

This brief article focuses on two aims: i) To investigate the in vitro pharmaco-dynamic
interactions of combining synthetic potent microtubule targeting anticancer agent, Fludelone …

Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a
promising drug target for novel antivirals against SARS-CoV-2. The marine natural product …

Dietary phytochemicals are currently being studied with great interest due to their ability to
regulate the epigenome resulting in prevention of cancer. Some natural botanicals have …

We developed a series of second-generation di-2-pyridyl ketone thiosemicarbazone (DpT)
and 2-benzoylpyridine thiosemicarbazone (BpT) ligands to improve the efficacy and safety …