In eukaryotic cells, a multitude of RNA-binding proteins play key roles in the
posttranscriptional regulation of gene expression. Characterization of these proteins has led …

The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

The HIV-1 Tat protein regulates transcription elongation through binding to the viral TAR
RNA stem-loop structure. We have isolated a novel 87 kDa cyclin C–related protein (cyclin …

The crystal structure of a large fragment of yeast type II DNA topoisomerase reveals a heart-
shaped dimeric protein with a large central hole. It provides a molecular model of the …

Human immunodeficiency virus, type 1 (HIV-1) 1 is the etiological agent for the acquired
immunodeficiency syndrome (AIDS). HIV-1 is a retrovirus that encodes a small nuclear …

Human immunodeficiency virus type 1 (HIV-1) primarily infects CD4+ T cells and cells of the
monocyte–macrophage lineage, resulting in immunodeficiency in an infected patient. Along …

The many important biological functions of RNA range from propagation of genetic
information to catalysis in RNA processing and protein synthesis [l]. This diverse array of …

The human immunodeficiency virus type-1 (HIV-1) Tat protein stimulates transcriptional
elongation. Tat is introduced to the transcription machinery by binding to the transactivation …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

When RNA and protein bind each other, recognition occurs almost invariably by “induced fit”
rather than by rigid “lock-and-key” docking (1, 2). The protein, the RNA, and sometimes both …