In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …

The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Abundant aromatic carboxylic acids exist in great structural diversity from nature and
synthesis. To date, the synthetically valuable decarboxylative functionalization of benzoic …

Natural products have been the main sources of new drugs. The different strategies have
been developed to find the new drugs based on natural products. The traditional and ethic …

As one of the major therapeutic options for cancer treatment, chemotherapy has limited
selectivity against cancer cells. Consequently, this therapeutic strategy offers a small …

In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an
increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold …

Antimicrobial peptides (AMPs) found in a wide range of animal, insect, and plant species are
host defense peptides forming an integral part of their innate immunity. Although the exact …

In the last decade, biological drugs have rapidly proliferated and have now become an
important therapeutic modality. This is because of their high potency, high specificity and …

In recent years, the peptide drug discovery field has shown a high level of dynamism, with
hundreds of academic groups working on this topic, the creation of new peptide-focused …

Although the pharmaceutical industry will remember 2020 as the year of COVID-19, it is
important to highlight that this year has been the second-best—together with 1996—in terms …