Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

The pH plays an important physiological role in nature and humans. pH varies from 1 to 8 in
human organs with tight regulation in blood and epithelia of barrier organs. The …

Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterized by eczematous
and pruritic skin lesions. In recent decades, the prevalence of AD has increased worldwide …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

Background Recent studies have suggested that epidermal barrier dysfunction contributes
to the development of atopic dermatitis (AD) and other allergic diseases. Objective We …

Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in
cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal …

Background Atopic dermatitis is the most common chronic inflammatory skin disorder,
affecting up to 20% of children and 10% of adults in industrialized countries. This highly …

Although, drugs are required in the various skin compartments such as viable epidermis,
dermis, or hair follicles, to efficiently treat skin diseases, drug delivery into and across the …

Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It often
precedes the development of food allergy and asthma. Recent insights into AD reveal …