Drug resistance is a major cause for therapeutic failure in non-small cell lung cancer
(NSCLC) leading to tumor recurrence and disease progression. Cell intrinsic mechanisms of …

The transcription factor Nrf2 (NF‐E2 related factor 2) is a master regulator of the cell
antioxidant response associated with tumor growth and resistance to cytotoxic treatments. In …

Purpose Endocrine resistance limits the efficacy of anti-estrogen therapies. Notch signaling
is involved in modulating tumor-associated macrophage (TAM) differentiation and is …

Non-small cell lung cancer (NSCLC) stemness and chemoresistance represent significant
barriers to successful treatment. Downregulation of microRNA 129 (miR-129) has been …

Ethnopharmacological relevance Panax notoginseng saponins (PNS) are the major
chemical constituents of Panax notoginseng (Burkill) FH Chen (Araliaceae), a medicinal …

Background Delta-tocotrienol (δT), an isomer of vitamin E, exhibits anticancer properties in
different cancer types including non-small-cell lung cancer (NSCLC). Yet, anti-invasive …

MicroRNA (miRNA)–mRNA interactions are important for understanding many biological
processes, including development, differentiation and disease progression, but their …

Simple Summary Resistance to chemoradiotherapy represents a fundamental problem in
modern oncology because it exposes patients to the potential negative side-effects of both …

Notch is a conserved developmental signaling pathway that is dysregulated in many cancer
types, most often through constitutive activation. Tumor cells with nuclear accumulation of …

Osteosarcoma is a malignant tumor that often occurs in adolescents. There is an urgent
need for new treatment options for osteosarcoma due to its poor prognosis after metastasis …