Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia

P Lemoine, N Zisapel - Expert opinion on pharmacotherapy, 2012 - Taylor & Francis
Introduction: Insomnia is common among the elderly. The use of hypnotic drugs in elderly
patients is frequently criticized owing to dependency, cognitive impairments, falls and …

Efficacy of melatonin and ramelteon for the acute and long‐term management of insomnia disorder in adults: A systematic review and meta‐analysis

J Maruani, E Reynaud, J Chambe… - Journal of Sleep …, 2023 - Wiley Online Library
Melatonin has gained growing interest as a treatment of insomnia, despite contradictory
findings, and a low level of evidence. A systematic review and meta‐analysis was conducted …

Melatonin effects on sleep quality and outcomes of COVID‐19 patients: an open‐label, randomized, controlled trial

SA Mousavi, K Heydari, H Mehravaran… - Journal of Medical …, 2022 - Wiley Online Library
This trial aims to evaluate the effectiveness of adding melatonin to the treatment protocol of
hospitalized coronavirus disease 2019 (COVID‐19) patients. This was an open‐label …

Prolonged‐release melatonin improves sleep quality and morning alertness in insomnia patients aged 55 years and older and has no withdrawal effects

P Lemoine, T Nir, M Laudon… - Journal of sleep …, 2007 - Wiley Online Library
Melatonin, secreted nocturnally by the pineal gland, is an endogenous sleep regulator.
Impaired melatonin production and complaints on poor quality of sleep are common among …

Efficacy of prolonged release melatonin in insomnia patients aged 55–80 years: quality of sleep and next-day alertness outcomes

AG Wade, I Ford, G Crawford… - … medical research and …, 2007 - Taylor & Francis
Objective: Melatonin, the hormone produced nocturnally by the pineal gland, serves as a
circadian time cue and sleep-anticipating signal in humans. With age, melatonin production …

The effect of melatonin, magnesium, and zinc on primary insomnia in long‐term care facility residents in Italy: a double‐blind, placebo‐controlled clinical trial

M Rondanelli, A Opizzi, F Monteferrario… - Journal of the …, 2011 - Wiley Online Library
OBJECTIVES: To determine whether nightly administration of melatonin, magnesium, and
zinc improves primary insomnia in long‐term care facility residents. DESIGN: Double‐blind …

Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing

Y Nussbaumer-Ochsner, J Ursprung, C Siebenmann… - Sleep, 2012 - academic.oup.com
Abstract Study Objective: Objective physiologic data on sleep and nocturnal breathing at
initial exposure and during acclimatization to high altitude are scant. We tested the …

The effect of prolonged-release melatonin on sleep measures and psychomotor performance in elderly patients with insomnia

R Luthringer, M Muzet, N Zisapel… - International clinical …, 2009 - journals.lww.com
Objectives of this study were to investigate the effects of prolonged-release melatonin 2 mg
(PRM) on sleep and subsequent daytime psychomotor performance in patients aged≥ 55 …

Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: associations with sleep quality and metabolic parameters

N Lasikiewicz, H Hendrickx, D Talbot, L Dye - Psychoneuroendocrinology, 2008 - Elsevier
The use of saliva samples is a practical and feasible method to explore basal diurnal cortisol
profiles in free-living research. This study explores a number of psychological and …

Insomnia may mediate the relationship between stress and anxiety: a cross-sectional study in university students

MD Manzar, M Salahuddin… - Nature and Science …, 2021 - Taylor & Francis
Background High perceived stress and anxiety disorders are usually comorbid with each
other, with stress often sequentially preceding the development of anxiety. While prior …