SHOX deficiency is the most frequent genetic growth disorder associated with isolated and
syndromic forms of short stature. Caused by mutations in the homeobox gene SHOX, its …

Hox genes encode evolutionarily conserved transcription factors that control skeletal
patterning in the developing embryo. They are expressed in regionally restricted domains …

The developmental trajectory of human skeletal myogenesis and the transition between
progenitor and stem cell states are unclear. We used single-cell RNA sequencing to profile …

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy
involving two topologically associating domains (TADs) located on either side of the gene …

Transposable elements (TEs) are DNA sequences that can insert elsewhere in the genome
and modify genome structure and gene regulation. The role of TEs in evolution is …

Allometric growth of the forelimb and hindlimb is a widespread phenomenon observed in
vertebrates. As a typical precocial bird, ducks exhibit more advanced development of their …

Despite the great diversity of vertebrate limb proportion and our deep understanding of the
genetic mechanisms that drive skeletal elongation, little is known about how individual …

Esophageal squamous cell carcinoma (ESCC) is the most common histological type in
China. MicroRNAs are endogenously expressed in mammals and play a significant role in …

The key molecular interactions governing vertebrate limb bud development are a paradigm
for studying the mechanisms controlling progenitor cell proliferation and specification during …

Bone protrusions provide stable anchoring sites for ligaments and tendons and define the
unique morphology of each long bone. Despite their importance, the mechanism by which …