Advances in nano-based drug delivery systems for the management of cytokine influx-mediated inflammation in lung diseases

N Gulati, DK Chellappan, R MacLoughlin… - Naunyn-Schmiedeberg's …, 2024 - Springer
Asthma, lung cancer, cystic fibrosis, tuberculosis, acute respiratory distress syndrome,
chronic obstructive pulmonary disease, and COVID-19 are few examples of inflammatory …

Polysaccharide-based platforms for nasal delivery: design, features, and perspectives

E Elmowafy, ME Soliman - Journal of Pharmaceutical Investigation, 2023 - Springer
Background Polysaccharides acceded by the Food and Drug Administration are among the
most exploitable polymers for fabricating nasally applied vehicles containing therapeutically …

An eosinophil peroxidase activity assay accurately predicts eosinophilic chronic rhinosinusitis

KA Smith, AS Gill, CE Pollard, JS Sumsion… - Journal of Allergy and …, 2023 - Elsevier
Background A definitive diagnosis of eosinophilic chronic rhinosinusitis (eCRS) requires
invasive surgical tissue sampling and histologic enumeration of intact eosinophils …

[HTML][HTML] Functional nanostructured lipid carrier-enriched hydrogels tailored to repair damaged epidermal barrier

R Joukhadar, L Nižić Nodilo, J Lovrić, A Hafner, I Pepić… - Gels, 2024 - mdpi.com
In this study, a functional nanostructured lipid carriers (NLCs)-based hydrogel was
developed to repair the damaged epidermal skin barrier. NLCs were prepared via a high …

Chitosan-based thermogelling system for nose-to-brain donepezil delivery: optimising formulation properties and nasal deposition profile

M Perkušić, L Nižić Nodilo, I Ugrina, D Špoljarić… - Pharmaceutics, 2023 - mdpi.com
Donepezil nasal delivery strategies are being continuously investigated for advancing
therapy in Alzheimer's disease. The aim of this study was to develop a chitosan-based …

Formulation and Evaluation of Itraconazole Novel Nanosuspension-Based In Situ Gelling System for Vaginal Candidiasis Using 24 Factorial Design

H Parsana, M Chotaliya, K Dudhat - BioNanoScience, 2023 - Springer
The goal of the current study was to develop an in situ vaginal drug delivery system for
itraconazole based on nanosuspension to improve its solubility and bioavailability. By using …

Thermoreversible Carbamazepine In Situ Gel for Intranasal Delivery: Development and In Vitro, Ex Vivo Evaluation

K Mohananaidu, B Chatterjee, F Mohamed… - AAPS …, 2022 - Springer
Over the past decade, intranasal (IN) delivery has been gaining attention as an alternative
approach to conventional drug delivery routes targeting the brain. Carbamazepine (CBZ) is …

Current status and prospects of nanosuspension for improved transdermal targeted drug delivery

C Yang, W Wang, L Xue, Y Wang - Journal of Drug Delivery Science and …, 2024 - Elsevier
As a non-invasive dosage form, transdermal targeted drug delivery system avoids first-pass
effect, improves and maintains blood drug concentration, reduces gastrointestinal …

[HTML][HTML] Development of an Intranasal In Situ System for Ribavirin Delivery: In Vitro and In Vivo Evaluation

IB Mikhel, EO Bakhrushina, DA Petrusevich… - Pharmaceutics, 2024 - mdpi.com
Recently, ribavirin has demonstrated effectiveness in treating glioblastoma through
intranasal administration utilizing the nose-to-brain delivery route. Enhancing ribavirin's …

[HTML][HTML] Polysaccharides: New Frontiers for Nasal Administration of Medicines

A Clementino, G Climani, A Bianchera, F Buttini… - Polysaccharides, 2025 - mdpi.com
The nasal cavity has become a focal point for drug delivery research. Beyond its use in
treating local diseases, the nasal route is appealing due its ability to deliver systemically …