Role of diagnostics in epidemiology, management, surveillance, and control of leptospirosis
A One Health approach to the epidemiology, management, surveillance, and control of
leptospirosis relies on accessible and accurate diagnostics that can be applied to humans …
leptospirosis relies on accessible and accurate diagnostics that can be applied to humans …
Research progress of CRISPR-based biosensors and bioassays for molecular diagnosis
K Chen, Z Shen, G Wang, W Gu, S Zhao… - … in Bioengineering and …, 2022 - frontiersin.org
CRISPR/Cas technology originated from the immune mechanism of archaea and bacteria
and was awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing …
and was awarded the Nobel Prize in Chemistry in 2020 for its success in gene editing …
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing
Extensive testing is essential to break the transmission of SARS-CoV-2, which causes the
ongoing COVID-19 pandemic. Here, we present a CRISPR-based diagnostic assay that is …
ongoing COVID-19 pandemic. Here, we present a CRISPR-based diagnostic assay that is …
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
Abstract Background The CRISPR-Cas13 system is an RNA-guided RNA-targeting system
and has been widely used in transcriptome engineering with potentially important clinical …
and has been widely used in transcriptome engineering with potentially important clinical …
A novel miniature CRISPR-Cas13 system for SARS-CoV-2 diagnostics
Rapid, point-of-care (POC) diagnostics are essential to mitigate the impacts of current (and
future) epidemics; however, current methods for detecting severe acute respiratory …
future) epidemics; however, current methods for detecting severe acute respiratory …
A field-deployable method for single and multiplex detection of DNA or RNA from pathogens using Cas12 and Cas13
L Li, C Duan, J Weng, X Qi, C Liu, X Li, J Zhu… - Science China Life …, 2022 - Springer
For some Cas nucleases, trans-cleavage activity triggered by CRISPR/Cas-mediated cis-
cleavage upon target nucleic acid recognition has been explored for diagnostic detection …
cleavage upon target nucleic acid recognition has been explored for diagnostic detection …
Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice
The CRISPR-Cas13 system is an RNA-guided RNA-targeting system, and has been widely
used in transcriptome engineering with potentially important clinical applications. However …
used in transcriptome engineering with potentially important clinical applications. However …
Combating infectious diseases with synthetic biology
Over the past decades, there have been numerous outbreaks, including parasitic, fungal,
bacterial, and viral infections, worldwide. The rate at which infectious diseases are emerging …
bacterial, and viral infections, worldwide. The rate at which infectious diseases are emerging …
Harnessing CRISPR-Cas to combat COVID-19: From diagnostics to therapeutics
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), remains a global threat with an ever-increasing death toll …
coronavirus 2 (SARS-CoV-2), remains a global threat with an ever-increasing death toll …
The role of chemical biology in the fight against SARS-CoV-2
GM Burslem - Biochemical Journal, 2021 - portlandpress.com
Since late 2019, biomedical labs all over the world have been struggling to cope with the
'new normal'and to find ways in which they can contribute to the fight against COVID-19. In …
'new normal'and to find ways in which they can contribute to the fight against COVID-19. In …