Biocatalysis has revolutionized chemical synthesis, providing sustainable methods for
preparing various organic molecules. In enzyme-mediated organic synthesis, most reactions …

Excited (triplet) states offer a myriad of attractive synthetic pathways, including
cycloadditions, selective homolytic bond cleavages and strain-release chemistry …

Naturally evolved enzymes, despite their astonishingly large variety and functional diversity,
operate predominantly through thermochemical activation. Integrating prominent …

Conspectus Harnessing biocatalysts for novel abiological transformations is a longstanding
goal of synthetic chemistry. Combining the merits of biocatalysis and photocatalysis allows …

The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …

Heteroatom-containing motifs are one of the most privileged scaffolds for pharmaceuticals,
agrochemicals, and functional materials. Transition-metal-catalyzed carbon–heteroatom …

Artificial enzymes with new-to-nature reactivity are highly desirable to expand the repertoire
of biocatalysis for sustainable synthesis. To this end, artificial photoenzymes embedded with …

Conspectus Metalloproteins establish a comprehensive molecular space by combining
inorganic cofactors with protein environments. The chemical interplay between a metal …

Cerium photoredox catalysis has emerged as a powerful strategy to activate molecules
under mild conditions. Radical intermediates are formed using visible light and simple …

Highlights•Halogenation is a powerful strategy to tune physicochemical features of organic
molecules.•Synthetic metabolism can be tailored for the incorporation of halogen …