Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

Fosfomycin, a natural product antibiotic, has been in use for> 20 years in Spain, Germany,
France, Japan, Brazil, and South Africa for urinary tract infections (UTIs) and other …

Gram-negative bacteria surround their cytoplasmic membrane with a peptidoglycan (PG)
cell wall and an outer membrane (OM) with an outer leaflet composed of lipopolysaccharide …

Phosphorus-containing drugs belong to an important class of therapeutic agents and are
widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can …

Epoxide functional group is a part of several natural as well as synthetic compounds.
Irrespective of the role of epoxide group in drug efficacy and the use of epoxide compounds …

The doom and gloom of antibiotic resistance dominates public perception of this drug class.
Many believe the world has entered the post-antibiotic era. Classic and modern approaches …

Escherichia coli is one of the most common pathogens in nosocomial and community-
acquired infections in humans. Fosfomycin is a broad-spectrum antibiotic which inhibits …

Deep mutational scanning is a powerful approach to investigate a wide variety of research
questions including protein function and stability. Here, we perform deep mutational …

Aim: ESBL-producing and bacterial biofilms-forming Escherichia coli are associated with
antimicrobial treatment failure. This study aimed to investigate the phenotypic resistance …

Tuberculosis (TB) is the second leading cause of human mortality from infectious diseases
worldwide. The WHO reported 1.3 million deaths and 8.6 million new cases of TB in 2012 …