The influenza A virus was isolated for the first time in 1931, and the first attempts to develop
a vaccine against the virus began soon afterwards. In addition to causing seasonal …

Despite the availability of yearly vaccinations, influenza continues to cause seasonal, and
pandemic rises in illness and death. An error prone replication mechanism results in …

The pig is an important agricultural species and powerful biomedical model. We have
established the pig, a large natural host animal for influenza with many physiological …

The nonhuman primate (NHP) has always been a limited resource for pharmaceutical
research with ongoing efforts to conserve. This is due to their inherent biological properties …

Introduction: Liposomes have been extensively investigated as drug delivery vehicles.
Immunoliposomes (ILs) are antibody-conjugated liposomes designed to selectively target …

The antigenic diversity of human influenza viruses represents a challenge to the
development of vaccines with durable immune protection. In addition, small molecule anti …

By their very nature, great advances in immunology are usually underpinned by experiments
carried out in animal models and inbred lines of mice. Also, their corresponding knock-out or …

Influenza viruses are an ongoing threat to humans and are endemic in pigs, causing
considerable economic losses to farmers. Pigs are also a source of new viruses potentially …

Abstract mAbs are a possible adjunct to vaccination and drugs in treatment of influenza virus
infection. However, questions remain whether small animal models accurately predict …

Efficient identification of human monoclonal antibodies targeting specific antigenic sites is
pivotal for advancing vaccines and immunotherapies against infectious diseases and …