The role of serotonin in drug use and addiction

CP Müller, JR Homberg - Behavioural brain research, 2015 - Elsevier
The use of psychoactive drugs is a wide spread behaviour in human societies. The
systematic use of a drug requires the establishment of different drug use-associated …

Anti‐drug vaccines to treat substance abuse

BM Kinsey, DC Jackson… - Immunology and cell …, 2009 - Wiley Online Library
Substance abuse is a growing world‐wide problem. The big four drugs of abuse that might
lend themselves to immunotherapy are nicotine, cocaine, morphine/heroin and …

Association of the HTR2A gene with alcohol and heroin abuse

J Cao, X Liu, S Han, CK Zhang, Z Liu, D Li - Human Genetics, 2014 - Springer
Positive genetic associations of rs6313 (102T/C at exon 1) and rs6311 (− 1438A/G) on the 5-
hydroxytryptamine (serotonin) 2A receptor gene (HTR2A or 5-HT2A) were reported for …

'Smoking genes': a genetic association study

Z Verde, C Santiago, JM Rodríguez González-Moro… - PloS one, 2011 - journals.plos.org
Some controversy exists on the specific genetic variants that are associated with nicotine
dependence and smoking-related phenotypes. The purpose of this study was to analyse the …

Negotiating imagined genetic communities: unity and diversity in Brazilian science and society

M Kent, RV Santos, P Wade - American Anthropologist, 2014 - Wiley Online Library
In this article, we explore the ways in which genetic research reconfigures historically rooted
debates on race and national identity by analyzing the intense debates that have taken …

Molecular genetic approaches to studying the externalizing spectrum

IR Gizer, JM Otto, JM Ellingson - The Oxford handbook of …, 2015 - books.google.com
Molecular genetic studies of psychiatric traits, including externalizing behaviors, aim to
further our understanding of etiology by identifying specific genetic vulnerabilities that give …

Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions

D Harmey, PR Griffin, PJ Kenny - Nicotine & Tobacco Research, 2012 - academic.oup.com
Introduction: The vast majority of tobacco smokers seeking to quit will relapse within the first
month of abstinence. Currently available smoking cessation agents have limited utility in …

Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse

AI Herman, KN Balogh - Substance abuse and rehabilitation, 2012 - Taylor & Francis
Serotonin (5-hydroxytryptamine [5-HT]) is an important neurotransmitter implicated in
regulating substance-use disorder (SUD) acquisition, maintenance, and recovery. During …

MR and GR functional SNPs may modulate tobacco smoking susceptibility

DL Rovaris, NR Mota, LA De Azeredo… - Journal of Neural …, 2013 - Springer
A number of studies have demonstrated that stress is involved in all aspects of smoking
behavior, including initiation, maintenance and relapse. The mineralocorticoid (MR) and …

Cigarette smoking in young adults: the influence of the HTR2A T102C polymorphism and punishment sensitivity

MJ White, RMD Young, CP Morris… - Drug and Alcohol …, 2011 - Elsevier
BACKGROUND: The C allele of a common polymorphism of the serotonin 2A receptor
(HTR2A) gene, T102C, results in reduced synthesis of 5-HT2A receptors and has been …