Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

There is growing evidence that oxidative stress contributes to hypertension. Oxidative stress
can precede the development of hypertension. In almost all models of hypertension, there is …

Cardiovascular problems are a major cause of morbidity and mortality in patients with
autosomal-dominant polycystic kidney disease (ADPKD). Hypertension is a common early …

Asymmetric (NG, NG)-dimethylarginine (ADMA) inhibits nitric oxide (NO) synthases (NOS).
ADMA is a risk factor for endothelial dysfunction, cardiovascular mortality, and progression …

Asymmetric (NG, NG) dimethylarginine (ADMA) is present in plasma and cells. It can inhibit
nitric oxide synthase (NOS) that generates nitric oxide (NO) and cationic amino acid …

Hypertension is common and occurs in a majority of autosomal dominant polycystic kidney
disease (ADPKD) patients before the loss of kidney function. Hypertension relates to …

Transient receptor potential (TRP) proteins constitute a large non-voltage-gated cation
channel superfamily, activated polymodally by various physicochemical stimuli, and are …

The idea that asymmetric dimethylarginine (ADMA) accumulation may be a cardiovascular
risk factor in patients with end-stage renal disease was advanced by Vallance in 1992 …

An intact microcirculation is vital for diffusion of oxygen and nutrients and for removal of
toxins of every organ and system in the human body. The functional and/or anatomical loss …

Whether changes in renal blood flow (RBF) are associated with and possibly contribute to
cystic disease progression in autosomal dominant polycystic kidney disease (ADPKD) has …