Kinase-targeted cancer therapies: progress, challenges and future directions
KS Bhullar, NO Lagarón, EM McGowan, I Parmar… - Molecular cancer, 2018 - Springer
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
The functional diversity of Aurora kinases: a comprehensive review
E Willems, M Dedobbeleer, M Digregorio, A Lombard… - Cell division, 2018 - Springer
Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …
Teratozoospermia: spotlight on the main genetic actors in the human
C Coutton, J Escoffier, G Martinez… - Human reproduction …, 2015 - academic.oup.com
BACKGROUND Male infertility affects> 20 million men worldwide and represents a major
health concern. Although multifactorial, male infertility has a strong genetic basis which has …
health concern. Although multifactorial, male infertility has a strong genetic basis which has …
The aurora kinases in cell cycle and leukemia
B Goldenson, JD Crispino - Oncogene, 2015 - nature.com
The Aurora kinases, which include Aurora A (AURKA), Aurora B (AURKB) and Aurora C
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
(AURKC), are serine/threonine kinases required for the control of mitosis (AURKA and …
Aurora kinase inhibitors: current status and outlook
V Bavetsias, S Linardopoulos - Frontiers in oncology, 2015 - frontiersin.org
The Aurora kinase family comprises of cell cycle-regulated serine/threonine kinases
important for mitosis. Their activity and protein expression are cell cycle regulated, peaking …
important for mitosis. Their activity and protein expression are cell cycle regulated, peaking …
Genetic interactions between the aurora kinases reveal new requirements for AURKB and AURKC during oocyte meiosis
AL Nguyen, D Drutovic, BN Vazquez, W El Yakoubi… - Current Biology, 2018 - cell.com
Errors in chromosome segregation during female meiosis I occur frequently, and aneuploid
embryos account for 1/3 of all miscarriages in humans [1]. Unlike mitotic cells that require …
embryos account for 1/3 of all miscarriages in humans [1]. Unlike mitotic cells that require …
Functions of Aurora kinase C in meiosis and cancer
SM Quartuccio, K Schindler - Frontiers in cell and developmental …, 2015 - frontiersin.org
The mammalian genome encodes three Aurora kinase protein family members: A, B, and C.
While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body …
While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body …
Recent advances of cell-cycle inhibitor therapies for pediatric cancer
CC Mills, EA Kolb, VB Sampson - Cancer research, 2017 - AACR
This review describes the pivotal roles of cell-cycle and checkpoint regulators and discusses
development of specific cell-cycle inhibitors for therapeutic use for pediatric cancer. The …
development of specific cell-cycle inhibitors for therapeutic use for pediatric cancer. The …
Haspin kinase regulates microtubule-organizing center clustering and stability through Aurora kinase C in mouse oocytes
AZ Balboula, AL Nguyen, AS Gentilello… - Journal of Cell …, 2016 - journals.biologists.com
Meiotic oocytes lack classic centrosomes and, therefore, bipolar spindle assembly depends
on clustering of acentriolar microtubule-organizing centers (MTOCs) into two poles …
on clustering of acentriolar microtubule-organizing centers (MTOCs) into two poles …