Hydroxycinnamic acid derivatives are important class of polyphenolic compounds originated
from the Mavolanate-Shikimate biosynthesis pathways in plants. Several simple phenolic …

In mammals, seven members of the sirtuin protein family known as class III histone
deacetylase have been identified for their characteristic features. These distinguished …

Progressive accumulation of defective mitochondria is a common feature of aged cells.
SIRT3 is a NAD+-dependent protein deacetylase that regulates mitochondrial function and …

Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently
been attracting markedly increasing interest. Aging is marked by a systemic decrease in …

The manner in which insulin resistance impinges on hepatic mitochondrial function is
complex. Although liver insulin resistance is associated with respiratory dysfunction, the …

Caloric restriction, fasting, and exercise have long been recognized for their neuroprotective
and lifespan-extending properties; however, the underlying mechanisms of these …

Life as we know it cannot exist without the nucleotide nicotinamide adenine dinucleotide
(NAD). From the simplest organism, such as bacteria, to the most complex multicellular …

Reactive oxygen species (ROS) are a family of compounds that can oxidatively damage
cellular macromolecules and may influence lifespan. Sirtuins are a conserved family of …

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin
resistance, mitochondrial dysfunction, inflammation, and oxidative stress. As a group of …

With changing lifestyles, non-alcoholic fatty liver disease (NAFLD) has become the most
prevalent liver disease worldwide. A substantial increase in the incidence, mortality, and …