The adrenal cortex undergoes multiple structural and functional rearrangements to satisfy
the systemic needs for steroids during fetal life, postnatal development, and adulthood. A …

The increase in the incidence of cardiovascular diseases (CVDs) and kidney disease has
stimulated research for strategies that could prevent, rather than just treat, both …

FRA1 (FOSL1) is a transcription factor and a member of the activator protein-1 superfamily.
FRA1 is expressed in most tissues at low levels, and its expression is robustly induced in …

Glucocorticoids (GCs) are steroid hormones fundamental to the body's normal physiological
functions and are pivotal in fetal growth and development. During gestation, the mother's …

The field of cardiovascular fetal programming has emphasized the importance of the uterine
environment on postnatal cardiovascular health. Studies have linked increased fetal …

Dexamethasone has been widely used in clinical practice to promote fetal lung maturity and
reduce neonatal respiratory distress syndrome and perinatal mortality. Nevertheless, its …

The prevalence of diabetes in children and adolescents has been rising gradually, which is
relevant to adverse environment during development, especially prepartum. We aimed to …

Fetal programming is the concept that maternal stressors during critical periods of fetal
development can alter offspring phenotypes postnatally. Excess glucocorticoids can interact …

The epigenetic regulation of nuclear factor erythroid 2-related factor 2 (Nrf2), a pivotal redox
transcription factor, plays a crucial role in maintaining cellular homeostasis. Recent research …

In recent decades, both clinical and animal studies have shown that fetal growth restriction
(FGR), caused by exposure to adverse uterine environments, is a risk factor for hypertension …