Diagnosis for latent tuberculosis infection: new alternatives

C Carranza, S Pedraza-Sanchez… - Frontiers in …, 2020 - frontiersin.org
Latent tuberculosis infection (LTBI) is a subclinical mycobacterial infection defined on the
basis of cellular immune response to mycobacterial antigens. The tuberculin skin test (TST) …

Vaccines against tuberculosis: where are we and where do we need to go?

THM Ottenhoff, SHE Kaufmann - PLoS pathogens, 2012 - journals.plos.org
In this review we discuss recent progress in the development, testing, and clinical evaluation
of new vaccines against tuberculosis (TB). Over the last 20 years, tremendous progress has …

LTBI: latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement

U Mack, GB Migliori, M Sester… - European …, 2009 - Eur Respiratory Soc
Tuberculosis control relies on the identification and preventive treatment of individuals who
are latently infected with Mycobacterium tuberculosis. However, direct identification of latent …

Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis

T Prezzemolo, G Guggino, MP La Manna… - Frontiers in …, 2014 - frontiersin.org
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …

Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis

E Petruccioli, TJ Scriba, L Petrone… - European …, 2016 - Eur Respiratory Soc
New approaches to control the spread of tuberculosis (TB) are needed, including tools to
predict development of active TB from latent TB infection (LTBI). Recent studies have …

High functional diversity in Mycobacterium tuberculosis driven by genetic drift and human demography

R Hershberg, M Lipatov, PM Small, H Sheffer… - PLoS …, 2008 - journals.plos.org
Mycobacterium tuberculosis infects one third of the human world population and kills
someone every 15 seconds. For more than a century, scientists and clinicians have been …

[HTML][HTML] Initiation and regulation of T-cell responses in tuberculosis

KB Urdahl, S Shafiani, JD Ernst - Mucosal immunology, 2011 - Elsevier
Tuberculosis (TB) poses a great challenge to immunologists, as it represents a chronic
infection characterized by persistence of the pathogen despite development of antigen …

The risk of tuberculosis in transplant candidates and recipients: a TBNET consensus statement

D Bumbacea, SM Arend, F Eyuboglu… - European …, 2012 - Eur Respiratory Soc
Tuberculosis (TB) is a possible complication of solid organ and hematopoietic stem cell
transplantation. The identification of candidates for preventive chemotherapy is an effective …

The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy

RL Leistikow, RA Morton, IL Bartek… - Journal of …, 2010 - Am Soc Microbiol
Mycobacterium tuberculosis survives in latently infected individuals, likely in a
nonreplicating or dormancy-like state. The M. tuberculosis DosR regulon is a genetic …