Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases
K Bunte, T Beikler - International journal of molecular sciences, 2019 - mdpi.com
Innate immunity represents the semi-specific first line of defense and provides the initial host
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …
response to tissue injury, trauma, and pathogens. Innate immunity activates the adaptive …
Th2 cells in health and disease
T Nakayama, K Hirahara, A Onodera… - Annual review of …, 2017 - annualreviews.org
Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity
S Kamerkar, C Leng, O Burenkova, SC Jang… - Science …, 2022 - science.org
Effectiveness of checkpoint immunotherapy in cancer can be undermined by
immunosuppressive tumor-associated macrophages (TAMs) with an M2 phenotype …
immunosuppressive tumor-associated macrophages (TAMs) with an M2 phenotype …
Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease
STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
(STAT) signaling pathway, a landmark in cell biology, provided a simple mechanism for …
Latent enhancers activated by stimulation in differentiated cells
According to current models, once the cell has reached terminal differentiation, the enhancer
repertoire is completely established and maintained by cooperatively acting lineage-specific …
repertoire is completely established and maintained by cooperatively acting lineage-specific …
Activation of STAT6 by STING is critical for antiviral innate immunity
STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular
cytokines. We now show that STAT6 is required for innate immune signaling in response to …
cytokines. We now show that STAT6 is required for innate immune signaling in response to …
Transcriptional regulation by STAT6
S Goenka, MH Kaplan - Immunologic research, 2011 - Springer
Signal transducer and activator of transcription (STAT) proteins are critical mediators of
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 …
Genome-wide CRISPR screens in T helper cells reveal pervasive crosstalk between activation and differentiation
Summary T helper type 2 (Th2) cells are important regulators of mammalian adaptive
immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a …
immunity and have relevance for infection, autoimmunity, and tumor immunology. Using a …
Genomic views of STAT function in CD4+ T helper cell differentiation
Signal transducer and activator of transcription (STAT) proteins are well known for their
essential roles in transmitting cytokine-mediated signals and specifying T helper (TH) cell …
essential roles in transmitting cytokine-mediated signals and specifying T helper (TH) cell …