▪ Abstract The high affinity receptor for immunoglobulin E (designated FcεRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …

Food anaphylaxis is now the leading known cause of anaphylactic reactions treated in
emergency departments in the United States. It is estimated that there are 30 000 …

This book is intended as an introductory text for use in immunology courses for medical
students, advanced undergraduate biology students, graduate students, and scientists in …

Fcγ‐receptors (FcγRs) represent the link between the humoral and cellular immune
responses. Via the binding to FcγR‐positive cells, immunocomplexes trigger several …

The distinguishing structural feature of immunoglobulin E (IgE), the antibody responsible for
allergic hypersensitivity, is the Cε2 domain pair that replaces the hinge region of IgG. The …

Food anaphylaxis is now the leading single cause of anaphylactic reactions treated in
emergency departments in Westernized countries. In the US, it is estimated that there are …

Cellular receptors for IgA (FcαR) mediate important protective functions. An extensive panel
of site-directed mutant IgAs was used to identify IgA residues critical for FcαR (CD89) …

Background Food allergy is a growing health problem with very limited treatment options.
Investigation of the immunologic pathways underlying allergic sensitization to foods in …

The binding of immunoglobulin E (IgE) to its high-affinity receptor (FcεRI) expressed on mast
cells and basophils is central to the development of an allergic reaction. Previous studies …

Natural antibodies (Ab) reacting with self antigens have been shown to be present in all
individuals. These autoantibodies (auto‐Ab) can be either pathogenic or non‐pathogenic …