Simple Summary Epigenetics studies the alteration of gene expression without changing
DNA sequence and very often, epigenetic dysregulation causes cancer. Alternative splicing …

Splicing is a fundamental process in pre-mRNA maturation. Whereas alternative splicing
(AS) enriches the diversity of the proteome, its aberrant regulation can drive oncogenesis …

The human aging process is associated with molecular changes and cellular degeneration,
resulting in a significant increase in cancer incidence with age. Despite their potential …

Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the
Philadelphia chromosome, and the current standard of care is the use of tyrosine kinase …

Simple Summary In Chronic Myeloid Leukemia (CML), intra-clonal heterogeneity is a major
factor in the response to tyrosine kinase inhibitors and in leukemia stem cell persistence …

The polycomb protein EZH2 is up-regulated in Chronic Myeloid Leukaemia (CML) and
associated with transcriptional reprogramming. Here we tested whether EZH2 might also act …

Chimeric RNAs are often associated with chromosomal rearrangements in cancer. In
addition, they are also widely detected in normal tissues, contributing to transcriptomic …

Notoriously known for their capacity to reconstitute hematological malignancies in vivo,
leukemic stem cells (LSCs) represent key drivers of therapeutic resistance and disease …

Background After many years of neglect in the field of alternative splicing, the importance of
intron retention (IR) in cancer has come into focus following landmark discoveries of …

Identifying resistance mutations in a drug target provides crucial information. Lentiviral
transduction creates multiple types of mutations due to the error-prone nature of the HIV-1 …