The quinolone antibiotics arose in the early 1960s, with the first examples possessing a
narrow-spectrum of activity with unfavorable pharmacokinetic properties. Over time, the …

Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times.
They have enjoyed over 30 years of clinical usage and become essential tools in the …

During the past 85 years of antibiotic use, we have learned a great deal about how these
'miracle'drugs work. We know the molecular structures and interactions of these drugs and …

Global tuberculosis incidence has declined marginally over the past decade, and
tuberculosis remains out of control in several parts of the world including Africa and Asia …

Antimicrobial substances may be synthetic, semisynthetic, or of natural origin (ie, from plants
and animals). Antimicrobials are considered “miracle drugs” and can determine if an …

Quinolone and fluoroquinolone antibiotics are potent, broad-spectrum agents commonly
used to treat a range of infections. Resistance to these agents is multifactorial and can be via …

Quinolones are one of the most commonly prescribed classes of antibacterials in the world
and are used to treat a variety of bacterial infections in humans. Because of the wide use …

Broad antibacterial spectrum, high oral bioavailability and excellent tissue penetration
combined with safety and few, yet rare, unwanted effects, have made the quinolones class of …

Quinolone antimicrobials are widely used in clinical medicine and are the only current class
of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …