Current updates and future perspectives on the management of renal cell carcinoma

D Singh - Life sciences, 2021 - Elsevier
Renal cell carcinoma (RCC) refers to renal-epithelial cancer, which represents over 90% of
kidney cancer and is a cause for cancer related deaths in the world. Studies suggested …

[HTML][HTML] Hormone signaling pathways as treatment targets in renal cell cancer

AM Czarnecka, M Niedzwiedzka… - International …, 2016 - spandidos-publications.com
Epidemiological, clinical, biochemical and genetic research has revealed that renal cell
cancer (RCC) etiology is hormone-related. It was shown that hormone receptors are …

Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis

E Im, SH Rhee, YS Park, C Fiocchi, Y Taché… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: The corticotrophin-releasing hormone (CRH) family of peptides
modulates intestinal inflammation and the CRH receptor 2 (CRHR2) suppresses postnatal …

Urocortins: actions in health and heart failure

MT Rademaker, AM Richards - Clinica Chimica Acta, 2017 - Elsevier
The urocortins (Ucns), endogenous peptides belonging to the corticotropin-releasing factor
(CRF) family, are increasingly recognized as having diverse and important multi-system …

Tumor specific epigenetic silencing of corticotropin releasing hormone-binding protein in renal cell carcinoma: association of hypermethylation and metastasis

H Tezval, N Dubrowinskaja, I Peters, C Reese, K Serth… - PloS one, 2016 - journals.plos.org
The relevance of Corticotropin Releasing Hormone (CRH)-system in human malignancies is
a question of growing interest. Here we investigated hypermethylation and epigenetic …

The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions

A Dimas, A Goussia, A Papoudou-Bai, A Politi… - Clinical and …, 2024 - Springer
Objectives To examine the relation of corticotropin-releasing hormone (CRH) family
peptides with inflammatory processes and oncogenesis, emphasizing in vulvar …

Corticotropin releasing hormone and urocortin 3 stimulate vascular endothelial growth factor expression through the cAMP/CREB pathway

SH Rhee, EL Ma, Y Lee, Y Taché, C Pothoulakis… - Journal of Biological …, 2015 - ASBMB
Colonic epithelium is the first line of defense against various pathological offenses in the gut.
Previous studies have shown that the peptides of the corticotropin-releasing hormone (CRH) …

The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress

A Arranz, M Venihaki, B Mol, A Androulidaki… - Molecular cancer, 2010 - Springer
Introduction Stress has been shown to be a tumor promoting factor. Both clinical and
laboratory studies have shown that chronic stress is associated with tumor growth in several …

Identification of Hypoxia–Immune-Related Gene Signatures and Construction of a Prognostic Model in Kidney Renal Clear Cell Carcinoma

S Bai, L Chen, Y Yan, X Wang, A Jiang, R Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Introduction: Kidney renal clear cell carcinoma (KIRC), a kind of malignant disease, is a
severe threat to public health. Tracking the information of tumor progression and conducting …

mRNA expression of CRF family members in urothelial bladder cancer

C Mavridis, M Venihaki, E Dermitzaki… - Oncology …, 2023 - spandidos-publications.com
The corticotropin-releasing factor (CRF) gene family includes the three urocortins (UCN1, 2
and 3) and the two receptors (CRFR1 and 2), which play a significant role in the physiology …