[HTML][HTML] The present and future of measurable residual disease testing in acute myeloid leukemia

JS Blachly, RB Walter, CS Hourigan - Haematologica, 2022 - ncbi.nlm.nih.gov
Considerable progress has been made in the past several years in the scientific
understanding of, and available treatments for, acute myeloid leukemia (AML). Achievement …

Consensus on the monitoring, treatment, and prevention of leukaemia relapse after allogeneic haematopoietic stem cell transplantation in China: 2024 update

Y Wang, YJ Chang, J Chen, M Han, JD Hu, J Hu… - Cancer Letters, 2024 - Elsevier
The consensus in 2018 from The Chinese Society of Haematology (CSH) on the monitoring,
treatment, and prevention of leukaemia relapse after allogeneic haematopoietic stem cell …

Perspective on measurable residual disease testing in acute myeloid leukemia

RB Walter - Leukemia, 2024 - nature.com
Half a century ago, the common occurrence of relapses in patients with acute myeloid
leukemia (AML) after achieving a morphologic remission, together with the inverse linear …

Prospective validation of the prognostic relevance of CD34+CD38 AML stem cell frequency in the HOVON-SAKK132 trial

LL Ngai, D Hanekamp, F Janssen… - Blood, The Journal …, 2023 - ashpublications.org
Measurable residual disease (MRD) assessment is incorporated in the clinical decision-
making of acute myeloid leukemia (AML) because of its prognostic value. 1 Therefore …

Peri-transplant flow-MRD assessment of cells with leukemic stem cells (LSC) associated phenotype in AML patients undergoing allogeneic stem cell transplantation in …

E Klyuchnikov, A Badbaran, R Massoud, P Freiberger… - Leukemia, 2024 - nature.com
Minimal residual disease (MRD) is a well-established prognostic marker that allows
subdivision of AML patients into different risk groups independently of the methods being …

Moving toward a conceptualization of measurable residual disease in myelodysplastic syndromes

E Schulz, PD Aplan, SD Freeman… - Blood Advances, 2023 - ashpublications.org
Approximately 90% of patients with myelodysplastic syndromes (MDSs) have somatic
mutations that are known or suspected to be oncogenic in the malignant cells. The genetic …

Understanding differential technologies for detection of MRD and how to incorporate into clinical practice

J Cloos, LL Ngai, M Heuser - Hematology, 2023 - ashpublications.org
Patient-and leukemia-specific factors assessed at diagnosis classify patients with acute
myeloid leukemia (AML) in risk categories that are prognostic for outcome. The induction …

Casein kinase 2 (CK2): A possible therapeutic target in acute myeloid leukemia

Ø Bruserud, H Reikvam - Cancers, 2023 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) is an aggressive blood cancer disease that
can only be cured by intensive anticancer treatment, and for several patients, allogeneic …

Measurable residual disease (MRD)-testing in haematological cancers: A giant leap forward or sideways?

Q Shen, X Gong, Y Feng, Y Hu, T Wang, W Yan… - Blood Reviews, 2024 - Elsevier
Measurable residual disease (MRD)-testing is used in many haematological cancers to
estimate relapse risk and to direct therapy. Sometimes MRD-test results are used for …

Novel tools for diagnosis and monitoring of AML

F Guijarro, M Garrote, N Villamor, D Colomer… - Current …, 2023 - mdpi.com
In recent years, major advances in the understanding of acute myeloid leukemia (AML)
pathogenesis, together with technological progress, have led us into a new era in the …