Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality in
children and young adults worldwide through epidemic or sporadic meningitis and/or …

Simulating cancer behavior across multiple biological scales in space and time, ie,
multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine …

Metabolic exchange mediates interactions among microbes, helping explain diversity in
microbial communities. As these interactions often involve a fitness cost, it is unclear how …

Network reconstructions are a common denominator in systems biology. Bottom–up
metabolic network reconstructions have been developed over the last 10 years. These …

Genome-scale constraint-based models of several organisms have now been constructed
and are being used for model driven research. A key issue that may arise in the use of such …

The advent of genome‐scale models of metabolism has laid the foundation for the
development of computational procedures for suggesting genetic manipulations that lead to …

We present the RAVEN (R econstruction, A nalysis and V isualization of M e tabolic N
etworks) Toolbox: a software suite that allows for semi-automated reconstruction of genome …

The interest in studying metabolic alterations in cancer and their potential role as novel
targets for therapy has been rejuvenated in recent years. Here, we report the development of …

Although the network topology of metabolism is well known, understanding the principles
that govern the distribution of fluxes through metabolism lags behind. Experimentally, these …

Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid cycle (TCA cycle) that
catalyses the hydration of fumarate into malate. Germline mutations of FH are responsible …