The adaptive immune system holds invaluable information on past and present immune
responses in the form of B and T cell receptor sequences, but we are limited in our ability to …

Recognition of antigens by T cell receptors (TCRs) is a key component of adaptive immunity.
Understanding the structures of these TCR interactions provides major insights into immune …

Cellular immunity relies on the ability of a T-cell receptor (TCR) to recognize a peptide (p)
presented by a class I major histocompatibility complex (MHC) receptor on the surface of a …

Background T cells form one of the key pillars of adaptive immunity. Using their surface
bound T cell antigen receptors (TCRs), these cells screen millions of antigens presented by …

T-cell receptor (TCR) structures are currently under-utilised in early-stage drug discovery
and repertoire-scale informatics. Here, we leverage a large dataset of solved TCR structures …

Cryptosporidium has gained much attention as a major cause of diarrhea worldwide. Here,
we present the first structure of H-2K b complexed with a decapeptide from Cryptosporidium …

T cell receptors (TCRs) that recognize cancer neoantigens are important for anti-cancer
immune responses and immunotherapy. Understanding the structural basis of TCR …

The human MHC transplantation loci (HLA-A,-B,-C,-DPB1,-DQB1,-DRB1) are the most
polymorphic in the human genome. It is generally accepted this polymorphism reflects a role …

T cell receptor (TCR) and TCR-peptide-major histocompatibility complex (pMHC) structure
prediction tools have developed rapidly following AlphaFold's success. While these deep …