The γ‐aminobutyric acid type A (GABAA) receptor represents an elementary switching
mechanism integral to the functioning of the central nervous system and a locus for the …

Benzodiazepines in clinical use have a range of pharmacological activities. Some eg
sedation, tolerance and addiction, are not welcome. Undesirable side-effects of drugs are …

The N-methyl-D-aspartate(NMDA) receptor is believed to play a major role in learning and in
excitotoxic neuronal damage associated with stroke and epilepsy. Pregnenolone sulfate, a …

The list of activities of plant flavonoids did not include effects on the central nervous system
(CNS) up to 1990, when our laboratory described the existence of natural anxiolytic …

Several lines of evidence suggest that 17β-estradiol (βE2) has neuroprotective properties.
The risk and severity of dementia are decreased in women who have received estrogen …

The ability of certain synthetic and endogenous steroids to modulate neuronal responses to
y-aminobutync acid (GABA) is well documented, but little is known of the effect of steroids on …

Benzodiazepines produce their pharmacological effects by regulating the interaction of
GABA with its recognition site on the GABA A receptor complex. In fact, the anxiolytic effect of …

We have shown previously that the neurosteroid pregnenolone sulfate acts as a positive
allostenc modulator at the N-methyl-D-aspartate(NMDA) receptor while inhibiting the …

Benzodiazepines are commonly used in the therapeutic treatment of anxiety, insomnia,
seizure disorders and certain kinds of spasticity. For years, knowledge of their mechanisms …

Benzodiazepines remain widely used for the treatment of anxiety disorders despite
prominent, often limiting side effects including sedation, muscle relaxation, and ataxia. A …