When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was
discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs …

The interferons (IFNs) were originally described over 50 years ago, identified by their ability
to confer viral resistance to cells. We now know that they are much more than just anti‐viral …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

Interferons (IFN) exert antiviral, immunomodulatory and cytostatic activities. IFN-α/β (type I
IFN) and IFN-λ (type III IFN) bind distinct receptors, but regulate similar sets of genes and …

The discovery and initial description of the interferon-λ (IFN-λ) family in early 2003 opened
an exciting new chapter in the field of IFN research. There are 3 IFN-λ genes that encode 3 …

Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to
an innate immune response that restricts virus replication and induces adaptive immunity. In …

Abstract Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities,
which remain poorly characterized. We herein show that most cell types expressed both …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Interferons (IFN s) are produced in response to virus infection and induce an antiviral state in
virtually all cell types. In addition to upregulating the transcription of genes that inhibit virus …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …