The liver is in charge of a wide range of critical physiological processes and it plays an
important role in activating the innate immune system which elicits the inflammatory events …

This review deals with the recent developments on the epigenetic effects of ethanol. A large
body of data have come from studies in liver and in neuronal systems and involve post …

Acetylation has recently emerged as an important mechanism for controlling a broad array of
proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, by …

Acute alcoholic hepatitis is characterized by disproportionate macrophage inflammatory
cytokine responses to bacterial lipopolysaccharide. Lack of knowledge of the underlying …

Background: Alcoholic and nonalcoholic steatohepatitis are leading causes of liver diseases
worldwide. While of different etiology, these share common pathophysiological mechanisms …

Ethanol exerts complex effects on human physiology and health. Ethanol is not only
addictive, but it is also a fetal teratogen, an adult neurotoxin, and an etiologic agent in …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide.
Despite improvements in HCC therapy, the prognosis for HCC patients remains poor due to …

Alcoholic liver disease (ALD) is a global concern affecting most of the population and
leading to the development of end‐stage liver disease. Metabolic alterations due to …

The widening web of epigenetic regulatory mechanisms also encompasses ethanol-induced
changes in the gastrointestinal (GI)–hepatic system. In the past few years, increasing …

Although the clinical manifestations of alcoholic liver disease are well-described, little is
known about the molecular basis of liver injury. Recent studies have indicated that ethanol …