Severe malaria: what's new on the pathogenesis front?

SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

X-ray fluorescence microscopy methods for biological tissues

MJ Pushie, NJ Sylvain, H Hou, MJ Hackett… - Metallomics, 2022 - academic.oup.com
Synchrotron-based X-ray fluorescence microscopy is a flexible tool for identifying the
distribution of trace elements in biological specimens across a broad range of sample sizes …

Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8+ T cells

J Liang, Y Shen, Y Wang, Y Huang, J Wang, Q Zhu… - Molecular Brain, 2022 - Springer
Cerebral malaria is the most serious complication of malaria infection, with 26% of surviving
children having neurological sequelae, which may be caused by neuron damage, but the …

The ins and outs of cerebral malaria pathogenesis: immunopathology, extracellular vesicles, immunometabolism, and trained immunity

F Sierro, GER Grau - Frontiers in Immunology, 2019 - frontiersin.org
Complications from malaria parasite infections still cost the lives of close to half a million
people every year. The most severe is cerebral malaria (CM). Employing murine models of …

A multimodal spectroscopic imaging method to characterize the metal and macromolecular content of proteinaceous aggregates (“amyloid plaques”)

KL Summers, N Fimognari, A Hollings, M Kiernan… - Biochemistry, 2017 - ACS Publications
Alzheimer's disease (AD) is a major international health and economic concern. A key
pathological feature of AD is so-called “amyloid-β-plaques”, or “Aβ-plaques”, which are …

Recent advances in analysis of trace elements in environmental samples by X-ray based techniques (IUPAC Technical Report)

R Terzano, MA Denecke, G Falkenberg… - Pure and Applied …, 2019 - degruyter.com
Trace elements analysis is a fundamental challenge in environmental sciences. Scientists
measure trace elements in environmental media in order to assess the quality and safety of …

[HTML][HTML] A bimodal fluorescence-Raman probe for cellular imaging

J Lin, ME Graziotto, PA Lay, EJ New - Cells, 2021 - mdpi.com
Biochemical changes in specific organelles underpin cellular function, and studying these
changes is crucial to understand health and disease. Fluorescent probes have become …

Concurrent glycogen and lactate imaging with FTIR spectroscopy to spatially localize metabolic parameters of the glial response following brain ischemia

MJ Hackett, NJ Sylvain, H Hou, S Caine… - Analytical …, 2016 - ACS Publications
Imaging energy metabolites as markers of the energy shuttle between glia and neurons
following ischemia is an ongoing challenge. Traditional microscopies in combination with …

Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation

J Lee, B Wen, EA Carter, V Combes… - The FASEB …, 2017 - Wiley Online Library
Microvesicles (MVs) are involved in cell‐cell interactions, including disease pathogenesis.
Nondestructive Fourier‐transform infrared (FTIR) spectra from MVs were assessed as a …

FTIR studies of the similarities between pathology induced protein aggregation in vivo and chemically induced protein aggregation ex vivo

RJ Tidy, V Lam, N Fimognari, JC Mamo… - Vibrational …, 2017 - Elsevier
Fourier transform infrared (FTIR) spectroscopy has been well documented to discriminate
between protein secondary structures, at the micron scale. This capability has enabled in …