Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

The function of mitophagy in cancer is controversial. ULK1 is critical for induction of
macroautophagy/autophagy and has a more specific role in mitophagy in response to …

The bromodomain and extraterminal (BET) family of proteins comprises four members—
BRD2, BRD3, BRD4 and the testis-specific isoform BRDT—that largely function as …

Akt, also known as protein kinase B, plays key roles in cell proliferation, survival and
metabolism. Akt hyperactivation contributes to many pathophysiological conditions …

The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Members of the highly conserved and ubiquitously expressed pleiotropic CK1 family play
major regulatory roles in many cellular processes including DNA-processing and repair …

The cell cycle is a collection of events by which cellular components such as genetic
materials and cytoplasmic components are accurately divided into two daughter cells. The …

We have shown previously that phosphorylation of Mdm2 by ATM and c-Abl regulates Mdm2-
p53 signaling and alters the effects of DNA damage in mice, including bone marrow failure …