MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by
degrading or repressing the translation of their target messenger RNAs. As miRNAs are …

Acute kidney injury (AKI) is an important health issue concerning∼ 50% of patients treated
in intensive care units. AKI mainly occurs after sepsis, acute ischemia, nephrotoxicity, or …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic renal
disease, primarily caused by germline mutation of PKD1 or PKD2, leading to end-stage …

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

Renal tubular cells frequently lose differentiation markers and physiological properties when
propagated in conventional cell culture conditions. Embedding cells in 3D …

Mitochondrial sequence variants affect phenotypic function, often through interaction with
the nuclear genome. These “mitonuclear” interactions have been linked both to evolutionary …

Polycystic kidney disease (PKD) is a significant cause of end-stage kidney failure and there
are few effective drugs for treating this inherited condition. Numerous aberrantly expressed …

Primary cilia are microtubule-based sensory cell organelles that are vital for tissue and
organ development. They act as an antenna, receiving and transducing signals, enabling …

Purpose of review microRNAs (miRNAs) are a class of small, evolutionarily conserved, non-
coding RNAs (ncRNAs) that function as inhibitors of post-transcriptional mRNA expression …