The application of scaffolding materials is believed to hold enormous potential for tissue
regeneration. Despite the widespread application and rapid advance of several tissue …

Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent
due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio …

Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

Significant amount of research efforts have been dedicated to the development of scaffolds
for tissue engineering. Although at present most of the studies are focused on non-load …

The reconstruction of musculoskeletal defects is a constant challenge for orthopaedic
surgeons. Musculoskeletal injuries such as fractures, chondral lesions, infections and tumor …

The extracellular matrix is produced by the resident cells in tissues and organs, and
secreted into the surrounding medium to provide biophysical and biochemical support to the …

Organ transplantation is an effective treatment for chronic organ dysfunctioning conditions.
However, a dearth of available donor organs for transplantation leads to the death of …

Large volume losses in weight bearing long bones are a major challenge in clinical practice.
Despite multiple innovations over the last decades, significant limitations subsist in current …

Objectives Induced membrane technique is a relatively new technique in the reconstruction
of large bone defects. It involves the implantation of polymethylmethacrylate (PMMA) cement …

The gold standard material for bone regeneration is still autologous bone, a mesenchymal
tissue that consists mainly of extracellular matrix (ECM)(90% v/v) and little cellular content …