Machine learning for the advancement of genome-scale metabolic modeling

P Kundu, S Beura, S Mondal, AK Das, A Ghosh - Biotechnology Advances, 2024 - Elsevier
Constraint-based modeling (CBM) has evolved as the core systems biology tool to map the
interrelations between genotype, phenotype, and external environment. The recent …

Progress and perspectives on developing Zymomonas mobilis as a chassis cell

Y YANG, B GENG, H SONG, Q HE, M HE… - Synthetic Biology …, 2021 - synbioj.cip.com.cn
Zymomonas mobilis, the only microorganism known to use the Entner-Doudoroff (ED)
pathway anaerobically, can produce ethanol naturally from glucose, fructose and sucrose …

Metabolic engineering of Zymomonas moblis for ethylene production from straw hydrolysate

Y He, B Wu, W Xia, KY Zhao, Y Qin, Q Tan… - Applied Microbiology …, 2021 - Springer
Biological ethylene production is a promising sustainable alternative approach for fossil-
based ethylene production. The high glucose utilization of Z. mobilis makes it as a promising …

Effects of down-regulation of ackA expression by CRISPR-dCpf1 on succinic acid production in Actinobacillus succinogenes

C Chen, P Zheng - AMB Express, 2023 - Springer
Succinic acid (SA), a key intermediate in the cellular tricarboxylic acid cycle (TCA), is a 4-
carbon dicarboxylic acid of great industrial value. Actinobacillus succinogenes can ferment …

Model-driven analysis of mutant fitness experiments improves genome-scale metabolic models of Zymomonas mobilis ZM4

WK Ong, DK Courtney, S Pan… - PLOS Computational …, 2020 - journals.plos.org
Genome-scale metabolic models have been utilized extensively in the study and
engineering of the organisms they describe. Here we present the analysis of a published …

[HTML][HTML] Construction and application of high-quality genome-scale metabolic model of Zymomonas mobilis to guide rational design of microbial cell factories

Y Wu, Q Yuan, Y Yang, D Liu, S Yang, H Ma - Synthetic and Systems …, 2023 - Elsevier
High-quality genome-scale metabolic models (GEMs) could play critical roles on rational
design of microbial cell factories in the classical Design-Build-Test-Learn cycle of synthetic …

Well Knowledge of the Physiology of Actinobacillus succinogenes to Improve Succinic Acid Production

A Salma, H Djelal, R Abdallah, F Fourcade… - Applied …, 2021 - mdpi.com
The anaerobic fermentation of glucose and fructose was performed by Actinobacillus
succinogenes 130Z in batch mode using three different volume of bioreactors (0.25, 1 and 3 …

Zymomonas mobilis metabolism: Novel tools and targets for its rational engineering

U Kalnenieks, KM Pappas, K Bettenbrock - Advances in Microbial …, 2020 - Elsevier
Zymomonas mobilis is an α-proteobacterium that interests the biofuel industry due to its
perfect ethanol fermentation yields. From its first description as a bacterial isolate in …

Insights on the Advancements of In Silico Metabolic Studies of Succinic Acid Producing Microorganisms: A Review with Emphasis on Actinobacillus succinogenes

W Dessie, Z Wang, X Luo, M Wang, Z Qin - Fermentation, 2021 - mdpi.com
Succinic acid (SA) is one of the top candidate value-added chemicals that can be produced
from biomass via microbial fermentation. A considerable number of cell factories have been …

[PDF][PDF] 运动发酵单胞菌底盘细胞研究现状及展望

杨永富, 耿碧男, 宋皓月, 何桥宁, 何明雄, 鲍杰… - 合成生物学, 2021 - researchgate.net
运动发酵单胞菌(Zymomonas mobilis) 是目前已知唯一能够在厌氧条件下利用Entner-
Doudoroff (ED) 途径代谢葡萄糖, 果糖和蔗糖产乙醇的革兰氏阴性细菌, 具有乙醇发酵速率高和 …