Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors
K Onomoto, K Onoguchi, M Yoneyama - Cellular & molecular …, 2021 - nature.com
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …
Pathogenesis of Zika virus infection
MI Giraldo, M Gonzalez-Orozco… - Annual Review of …, 2023 - annualreviews.org
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …
humans by mosquito vectors and represents an important health problem. Infections in …
Regulation of MAVS expression and signaling function in the antiviral innate immune response
Z Ren, T Ding, Z Zuo, Z Xu, J Deng, Z Wei - Frontiers in immunology, 2020 - frontiersin.org
Viral infection is controlled by host innate immune cells that express specialized receptors
for viral components. Engagement of these pattern recognition receptors triggers a series of …
for viral components. Engagement of these pattern recognition receptors triggers a series of …
Antiviral strategies targeting host factors and mechanisms obliging+ ssRNA viral pathogens
The ongoing COVID-19 pandemic, periodic recurrence of viral infections, and the
emergence of challenging variants has created an urgent need of alternative therapeutic …
emergence of challenging variants has created an urgent need of alternative therapeutic …
[HTML][HTML] Zika virus NS3 mimics a cellular 14-3-3-binding motif to antagonize RIG-I-and MDA5-mediated innate immunity
3-3 protein family members facilitate the translocation of RIG-I-like receptors (RLRs) to
organelles that mediate downstream RLR signaling, leading to interferon production. 14-3 …
organelles that mediate downstream RLR signaling, leading to interferon production. 14-3 …
The PB1 protein of influenza A virus inhibits the innate immune response by targeting MAVS for NBR1-mediated selective autophagic degradation
Y Zeng, S Xu, Y Wei, X Zhang, Q Wang, Y Jia… - PLoS …, 2021 - journals.plos.org
Influenza A virus (IAV) has evolved various strategies to counteract the innate immune
response using different viral proteins. However, the mechanism is not fully elucidated. In …
response using different viral proteins. However, the mechanism is not fully elucidated. In …
Differential roles of RIG-I like receptors in SARS-CoV-2 infection
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5
(MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate …
(MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate …
Mitochondrial interactome: a focus on antiviral signaling pathways
In the last years, proteomics has represented a valuable approach to elucidate key aspects
in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved …
in the regulation of type I/III interferons (IFNs) and autophagy, two main processes involved …
Viral strategies to antagonize the host antiviral innate immunity: an indispensable research direction for emerging virus-host interactions
N Chen, J Jin, B Zhang, Q Meng, Y Lu… - Emerging Microbes & …, 2024 - Taylor & Francis
The public's health is gravely at risk due to the current global outbreak of emerging viruses,
specifically SARS-CoV-2 and MPXV. Recent studies have shown that SARS-CoV-2 mutants …
specifically SARS-CoV-2 and MPXV. Recent studies have shown that SARS-CoV-2 mutants …
Roles of non-structural protein 4A in flavivirus infection
P Klaitong, DR Smith - Viruses, 2021 - mdpi.com
Infections with viruses in the genus Flavivirus are a worldwide public health problem. These
enveloped, positive sense single stranded RNA viruses use a small complement of only 10 …
enveloped, positive sense single stranded RNA viruses use a small complement of only 10 …