With an aging population, there is a proportional increase in the prevalence of intervertebral
disc diseases. Intervertebral disc diseases are the leading cause of lower back pain and …

Low back pain is the primary cause of disability and is highly associated with progression of
intervertebral disc degeneration. Current treatment options are limited and fail to address the …

Low back pain is a vital musculoskeletal disease that impairs life quality, leads to disability
and imposes heavy economic burden on the society, while it is greatly attributed to …

Introduction Low-back pain (LBP) has been correlated to the presence of intervertebral disc
(IVD) degeneration on T2-weighted (T2w) MRI. It remains challenging, however, to …

More than 619 million people in the world suffer from low back pain (LBP). As two potential
inducers of LBP, intervertebral disc degeneration (IVDD) and fat infiltration of paraspinal …

Low back pain (LBP) is a common health issue worldwide with a huge economic burden on
healthcare systems. In the United States alone, the cost is estimated to be $100 billion each …

Objective This study evaluates molecular, nutritional and biochemical alterations in human
intervertebral discs between middle and old age. Methods Twenty-eight human lumbar …

Purpose To investigate the feasibility and application of a novel imaging technique, a three-
dimensional dual adiabatic inversion recovery prepared ultrashort echo time (3D DIR-UTE) …

Background The end plate plays an important role in intervertebral disc degeneration
progression. The aim of the study was to examine the compositional and structural changes …

Background Low back pain (LBP) is a widespread problem and the leading cause of
disability worldwide. While the cause of LBP is multifactorial, several studies suggested that …