Spinal muscular atrophy (SMA), which results from the loss of expression of the survival of
motor neuron-1 (SMN1) gene, represents the most common genetic cause of pediatric …

Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs)
that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via …

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …

Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder
that manifests with personality changes, movement disorders, and cognitive decline. It is …

Alternative splicing (AS) is a crucial process to enhance gene expression driving organism
development. Interestingly, more than 95% of human genes undergo AS, producing multiple …

While many RNA-binding proteins (RBPs) bind RNA in a sequence-specific manner, their
sequence preferences alone do not distinguish known target RNAs from other potential …

Many biological processes involve gene-expression regulation by alternative splicing. Here,
we identify the splicing factor SRSF6 as a regulator of wound healing and tissue …

Alternative mRNA splicing is a major mechanism for gene regulation and transcriptome
diversity. Despite the extent of the phenomenon, the regulation and specificity of the splicing …

In addition to serving as a prosthetic group for enzymes and a hemoglobin structural
component, heme is a crucial homeostatic regulator of erythroid cell development and …

In addition to coding information, human exons contain sequences necessary for correct
splicing. These elements are known to be under purifying selection and their disruption can …